Catabolism of γ-globulin by the isolated perfused rat liver

Catabolism of plasma albumin by the perfused rat liver.

The liver is known to be a major site of plasmaprotein synthesis, but there is little information concerning its role in the catabolism of native plasma proteins. The ease with which the isolated perfused liver can be maintained under physiological conditions would appear to make it an ideal system for studying plasma-protein breakdown. However, the ability of the liver to take up particulate m...

SEQUESTRATION OF LEUKOCYTES BY THE ISOLATED PERFUSED RAT LUNG

The sequestration of rat leukocytes and bone marrow cells by the lung vasculature was studied using an isolated perfused rat lung preparation. The passage of latex particles of 7.6 µm in diameter and non-hematopoietic cells through the lung blood vessels was also studied. Leukocytes and bone marrow cells were reversibly sequestered from circulation, whereas, latex particles and non-hematop...

The isolated perfused rat liver.

The disposition of mefloquine has been investigated in the isolated perfused rat liver (IPRL) preparation after the administration of [C]mefloquine HCI (3.8 mg, 4 1 Ci, quinoline ring labeled). Mefloquine underwent avid hepatic uptake within 10 min of dosing. Also at this point, hepatic oxygen consumption was reduced markedly in four of the six IPRL preparations, but was restored completely by ...

Imatinib metabolism and disposition in isolated rat perfused liver

Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...

Synthesis of clotting factors by the isolated perfused rat liver.